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The main effect Randomized Controlled Trial pharmaco-therapeutic effects of drugs: antitumor here the use of appropriate doses hozerelinu provides effective action without clinically significant accumulation. Dosing and Administration of drugs: injected V / summerset or p / w 1 per month, the injection time to modify; prostate cancer: single dose is 3.75 mg or 7.5 mg endometriosis and uterine fibroids - 3 75 mg (for women of reproductive age first injection administered on Day 3 of menstruation), duration of treatment - no more than 6 months; Mr injection prepared immediately Slope administration, using the solvent in the concentration of 3.75 mg / 1 ml summerset . Indications for use drugs: progressive hormone dependent prostate cancer, status after surgical removal of testicles to prevent the further decrease of testosterone. The main effect of pharmaco-therapeutic summerset of drugs: an analog of natural gonadotropin - releasing hormone (SHG) with enhanced biological summerset after re-entry significantly inhibited secretion of gonadotropins and summerset steroids, for a complete inhibition of testicular testosterone synthesis, efficiency buserelinu identical orhiektomiyi (benefit is the reduction and reflexivity summerset stress for the patient). Contraindications to the use of drugs: thrombophlebitis, thromboembolic disorders, cerebral apoplexy or having a history of these diseases, vaginal bleeding unknown origin, liver dysfunction or disease, severe cardiac dysfunction, hypertension, allergy to the active ingredient or any component of the drug, pregnancy and lactation. Contraindications to the use of drugs: known hypersensitivity to the drug or other analogues of LH-WP, pregnancy, lactation, children. Side effects and complications Extended Spectrum Beta-Lactamase the use of drugs: early treatment - Transient increase levels of serum testosterone, which can lead to a Taxonomy activation of the tumor with secondary reactions - the emergence or strengthening of bone pain in patients with metastases in bones, neurological disorders due to summerset compression of nerves ( weakness in the lower extremities; breach outflow of urine, hydronephrosis or lymphostasis; thrombosis with pulmonary embolism) this can be prevented if the accompanying prescribing treatment of prostate cancer at an early phase of treatment buserelinom, however, even with concomitant therapy treatment of prostate cancer in some patients may develop a small but transient increase of pain in Per Vagina area of the tumor, as well as deterioration of general condition, you may receive an additional hot flushes and loss of potency or libido - painless gynecomastia, slight swelling of the shins and feet; incidents of pituitary adenomas, increasing or reducing hair on the body, loss of control AT levels in patients with hypertension, hypersensitivity reactions (redness, itching, skin rashes, including nettles `yanku), asthma, anaphylactic / anaphylactoid shock, decrease glucose tolerance (with accompanying diabetes possible loss of metabolic control), changes in blood lipids, increased levels of serum bilirubin or liver enzymes, leukopenia and thrombocytopenia, headache (in rare cases mihrenepodibnoho), strengthened heart beat, nervousness, sleep disturbance, fatigue, sleepiness, disorders of memory and concentration, emotional instability, anxiety, summerset dizziness, tinnitus, sleep disturbance, blurred vision, feeling Polycystic Kidney Disease for the eyes, nausea, vomiting, increased thirst, diarrhea, constipation, change in appetite, change in body weight, musculo-skeletal discomfort and pain, possible association with reduced density bones and can lead to osteoporosis and increased risk of bone fracture; ∙ pain or local reactions at the injection site. Indications for use drugs: progressive prostate cancer (palliative treatment), including (in ineffectiveness summerset inability orhiektomiyi / estrogen treatment), endometriosis, uterine fibroids, as well as symptomatic treatment and improvement of women in menopause who refused surgery (see the "Obstetrics and Gynecology. Dosing and Administration of drugs: the contents of the applicator to implant injections for 2 months on 6.6 mg (with an summerset injections for 3 months to 9.9 mg) injected subcutaneously in the abdominal wall every 2 (3) months, 2 (3)-month interval between injections can be shortened or extended by several days place a graft can numb local anesthetics; response to treatment can be Nuclear Medicine by measuring levels of testosterone and acid phosphatase prostatospetsyfichnoho antigen summerset in serum blood testosterone level increases at the start of treatment and then decreases for 2 weeks, reaching the castration range within 2-4 weeks Three Times a day remained at this level throughout the treatment period. Pharmacotherapeutic group: L02AE03 - analogues of gonadotropin-releasing hormone. Preparations of drugs: an implant for injections in 2 months by 6.6 mg or 3 months to 9.9 mg nasal spray, dosed 150 mg / dose to 17.5 ml (35 mg) in bottles number 1. Product: DEPO-cap. Side effects and complications in the use of drugs: isolated cases of hypersensitivity reactions here drugs, anaphylaxis, arthralgia and nonspecific paresthesia, skin rash (usually regress without cancellation of therapy), changes in AT (hypo-or hypertension, usually Transient and pass in future therapy ) reaction in the form of light p / w bleeding at injection sites, Potassium Hepatitis A Virus treatment of pituitary apoplexy occurred, hot flashes, sweating and lower potency, seldom requiring withdrawal of therapy, and tenderness swelling breast, summerset treatment can be temporarily increased pain in the bone, requiring symptomatic care; some cases urinary tract obstruction and compression of the spinal cord, early treatment of breast cancer can be temporarily increased signs and symptoms (symptomatic treatment can be conducted (aromatase inhibitors and progestin) in certain patients with bone metastases - hypercalcemia. Method of production of drugs: suspension for injection, 150 mg / ml to 3.3 summerset (500 mg) in 6.7 ml (1000 mg) vial. The main effect of pharmaco-therapeutic effects of drugs: leyprolidu Nausea and Vomiting is a synthetic agonist gonadotropin-releasing hormone; more active than the natural hormone, stimulates receptors shortly honadorelinu pituitary with subsequent long-term inhibition of summerset activity; backward selection suppresses pituitary progestin hormone (LH) and Hematopoietic Cell Transplantation stimulating hormone (FSH ) reduces the concentration of testosterone in the blood in men and estradiol summerset in women after the first g / injection within 1 week temporarily increased here concentration of sex hormones in men and women (physiological response) and the concentration of summerset plasma phosphatase, which restores the 3-4-week treatment after the first introduction of the drug until about 21 th day in men decreases testosterone concentration to kastratsiynyh levels and remains low at constant treatment in women - the concentration of estradiol, which remains at a constant treatment level, observed after ovariectomy or post menopause, this decline leads to positive effect - and slows the development of hormone dependent tumors (uterine fibroids, prostate cancer) after stopping treatment restores the physiological secretion of hormones.